CEBF funded wet labs, training physicians on new processing techniques

Our Impact

Blindness prevention and restoring sight transforms lives.

Current Research

CEBF is glad to confirm that even in the midst of challenging times, vision research continues. Cleveland Clinic Cole Eye Institute, University Hospitals Eye Institute, and Akron Children’s Hospital Vision Center are practicing safe and appropriate protocols to continue carrying out research despite COVID-19.

For a highlight of most recent research findings at Cleveland Clinic Cole Eye Institute, University Hospitals Eye Institute, and Akron Children’s Hospital Vision Center, watch the recording of CEBF’s most recent Virtual Vision Research Symposium.

Additional CEBF-Funded Research

Differential adaptations in rod outer segment disc membranes in different models of congenital stationary night blindness

  • Published by BBA – Biomembranes Journal.
  • Research conducted by Dr. Paul Park, Associate Professor in Dept. of Ophthalmology & Visual Sciences at Case Western Reserve University/University Hospitals.

2‐Hydroxypropyl‐β‐cyclodextrin reduces retinal cholesterol in wild type and Cyp27a1 ‐/‐ Cyp46a1 ‐/‐ mice with deficiency in the oxysterol production

  • Published by British Journal of Pharmacology.
  • Research conducted by Dr. Irina Pikuleva, Professor and Vice Chair for Research in Dept. of Ophthalmology & Visual Sciences at Case Western Reserve University.

The Cornea Image Atlas

This research was published as open access and is available to eye banks and surgeons throughout the world to advance their ability to evaluate the corneal donor tissue and improve donor tissue quality. This publication is a supplement to the Cornea journal and can be found here.

“As a community committed to providing the highest quality tissue possible for sight restoration, this atlas was developed, thanks in part to funds provided by the Cleveland Eye Bank Foundation, for the field of eye banking to share essential information.” – Jonathan H. Lass, MD. Charles I Thomas Professor, Case Western Reserve University, Department of Ophthalmology and Visual Sciences,Medical Director, Eversight, Medical Director, CIARC and REDIA

Cornea Preservation Time Study

This nationwide research, led by Jonathan Lass, MD with 36 participating clinical sites including over 50 corneal surgeons and 23 participating eye banks.   It was the first of its kind to study whether a cornea transplant surgery using donor corneas preserved beyond 8 days may be as successful as a surgery using donor corneas preserved less than 8 days.

My dad, Charlie, was just this magical person. When he was diagnosed with prostate and pancreatic cancer, he worried that his illness and chemotherapy would prevent him from fulfilling his wish to become an organ, eye and tissue donor. When my dad died on March 6, 2014, despite our sadness and despair, we got this phone call and we got to see joy. The legacy of my father could continue to live on through cornea donation, and someone else would get a beautiful gift of sight and a researcher could use his other cornea for impactful vision research.

Heather Fox

Eversight Operations

The Cleveland Eye Bank Foundation supported community and professional education activities through Eversight, that included promoting becoming an eye, organ and tissue donor, hospital, medical examiner and funeral director relations and activities, and ophthalmologist training in wet labs.

State of the Art Facilities

The Cleveland Eye Bank Foundation supported the construction of a new, state of the art office and laboratory in Cleveland for the eye bank (Eversight) that provides two processing rooms to pioneer new procedures in eye banking and a research center that will assist researchers in finding treatments and cures for blinding eye diseases.

Eversight Eye and Vision Grant Program

The Cleveland Eye Bank Foundation supported the Eversight grant program that awards grants to leading researchers at local institutions such as CWRU, Cleveland Clinic and University Hospitals Medical Center.

K.P. Connie Tam, Ph.D., Cleveland Clinic Lerner College of Medicine Award
Dr. Tan investigates whether antibacterial eye drops can help prevent or reduce the severity of the disease caused by Pseudomonas aeruginosa, a major bacterial pathogen, which can lead to serious eye infections. The implications of this project may lead to better optimization of the use of keratin antimicrobial eye drops, resulting in novel anti-infective therapeutics for combating infections of the cornea and other sites.

Padmanabhan Paranji Pattabiraman, Ph.D., CWRU
Pattabiraman researches primary open-angle glaucoma. He investigates the composition of material deposits using a combination of two techniques which will lead to a better understanding of the underlying mechanism of the material’s formation.

Sudha K. Iyengar, Ph.D., CWRU
Iyengar aims to change the paradigm for the classification of Fuch’s endorthelial corneal dystrophy and assist eye banks in selecting the best tissue for cornea transplants. Her goal is to identify biomarkers that will help doctors understand why some individuals are more at risk for the disease.